In vivo efficacy of antibiotic-eluting phospholipid coated implants
Implant-associated infection can be a serious problem for patients that receive orthopedic implants, such as hip and knee replacements. This is a common cause for early implant loosening, which requires revision surgeries and results in an even greater risk of infection. To address this issue, our lab has developed a novel electrospraying technique for applying phospholipid coatings to orthopedic implants. These coatings consist of two layers of 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), with antibiotic loaded in between layers. In vitro tests were performed to evaluate how modifications ...
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