Amyloid beta dimer/trimer: a potent stimulator of neuronal amyloid beta secretion and cofilin-actin rod formation, The
Amyloid beta (Aβ) peptides, a heterogeneous mixture of 39-43 amino acid peptides produced from β- and γ-secretase cleavage of the amyloid precursor protein (APP), are one of the causative agents of Alzheimer disease (AD). Although sensitive enzyme-linked immunosorbent assays (ELISAs) for specific rodent Aβ peptides and for total and specific human Aβ peptides have been commercially available, no commercial assay for total rodent Aβ was available when we began these studies. Such an assay is desirable to determine the effects of the human Aβ peptides on production of Aβ from cultured rodent ...
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Marsden, Ian Thomas
Bamburg, James R.
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Cellular prion protein-dependent signaling pathway for proinflammatory cytokine- and β-amyloid-induced cofilin-actin rod formation, A Author(s):Walsh, Keifer P.Date Issued:2014Format:born digital; masters thesesStimulus of oxidative stress in neurodegeneration leads to synaptic dysfunction and the eventual loss of neurons in the central nervous system. The actin cytoskeleton of neurons under acute or chronic stress experiences ...
Author(s):Mi, JianjieDate Issued:2012Format:born digital; masters thesesRod-like inclusions (rods), composed of actin saturated with cofilin, are induced in neurons by energetic and oxidative stresses, excitotoxic levels of glutamate, and amyloid beta treatment. Cofilin is an F-actin assembly ...