Rhodium-catalyzed cycloadditions between alkenyl isocyanates and alkynes: study of scope, mechanism and applications toward total synthesis
Rhodium-catalyzed cycloadditions between alkenyl isocyanates and unsymmetrical, internal alkynes has been studied. A wide variety of alkynes have proven successful components in the [2+2+2] cycloaddition. Excellent yields and enantioselectivities have been achieved in the resulting indolizidinone products. Furthermore, a single regioisomer is obtained for the vast majority of alkynes subjected to reaction conditions. A logical explanation for the highly regioselective insertion for internal, unsymmetrical alkynes was provided. Small variations in the electronics and/or steric bulk of the ...
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Friedman, Rebecca Ann Keller
Rovis, Tomislav, 1968-