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dc.contributor.advisorBlair, Carol D.
dc.contributor.authorLambert, Amy Julia
dc.contributor.committeememberChen, Chaoping
dc.contributor.committeememberLanciotti, Robert S.
dc.contributor.committeememberMiller, Barry R.
dc.contributor.committeememberBlack, William C.
dc.date.accessioned2007-01-03T04:51:44Z
dc.date.available2007-01-03T04:51:44Z
dc.date.issued2010
dc.description2010 Fall.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe genomic characterization, detection and evolution of arthropod-borne human pathogens and related viruses of the family Bunyaviridae are presented. This study began with the determination of primary nucleotide sequence data for a diversity of bunyaviruses of interest that were not previously characterized at the genetic level. Following molecular characterization, an RT-PCR strategy was designed, according to previously determined and newly derived nucleotide sequence data, to target S genomic segments of 47 viruses, including 29 arthropod-borne human pathogens, of the family Bunyaviridae. Following development, this strategy was used, in some instances with an expanded capacity for the detection of multiple segments of the bunyavirus genome, for the identification of arthropod-borne bunyaviruses of medical importance and novel circumstance at a global level. Phylogenetic analyses performed on nucleotide sequence data generated by these efforts facilitate an ancestral understanding of the discovered agents. Finally, advanced molecular and phylogenetic analyses of a subset of newly derived sequences are described here to facilitate an enhanced understanding of the evolution of Bunyaviridae.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierLambert_colostate_0053A_10182.pdf
dc.identifierETDF2010100013MIPA
dc.identifier.urihttp://hdl.handle.net/10217/44871
dc.languageEnglish
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019 - CSU Theses and Dissertations
dc.rightsCopyright of the original work is retained by the author.
dc.subjectmolecular
dc.subjectevolution
dc.subjectdetection
dc.subjectcharacterization
dc.subject.lcshArthropod vectors
dc.subject.lcshBunyaviruses -- Genetics
dc.subject.lcshMolecular biology
dc.subject.lcshMolecular evolution
dc.subject.lcshVector-pathogen relationships
dc.subject.lcshBunyaviridae
dc.titleGenomic characterization, detection and molecular evolution of arthropod-borne viruses of the family Bunyaviridae
dc.typeText
dcterms.rights.dplaThe copyright and related rights status of this item has not been evaluated (https://rightsstatements.org/vocab/CNE/1.0/). Please refer to the organization that has made the Item available for more information.
thesis.degree.disciplineMicrobiology, Immunology, and Pathology
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)


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