CSU Home
    • Login
    View Item 
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2000-2019 - CSU Theses and Dissertations
    • View Item
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2000-2019 - CSU Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Chronic wasting disease in transgenic mice and white-tailed deer - prion trafficking and pathogenesis

    Thumbnail
    Citable Link(s)
    http://hdl.handle.net/10217/39328
    Download/View
    2010_Summer_Seelig_Davis.pdf (4.978Mb)
    View full record
    Altmetrics
    Abstract
    Chronic wasting disease (CWD) is a naturally occurring, horizontally transmitted prion disease of cervids, including deer, elk and moose. Typical of all prion diseases, CWD is characterized by the forced conversion of the normal prion protein (PrPC) into a misfolded isoform (PrPCWD), which accumulates in tissues of the lymphoid, endocrine, and nervous systems. The accumulation of PrPCWD in the nervous system results in a constellation of 4 microscopic brain lesions: (1) neuronal degeneration and/or loss, (2) neuronal and neuropil degenerative spongiosis, (3) reactive gliosis with absent-to-minimal ...
    (For more, see "View full record.")
    Author(s)
    Seelig, Davis Martin

    Advisor(s)
    Hoover, Edward Arthur, 1942-

    Date Issued
    2010
    Format
    born digital; doctoral dissertations
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Microbiology, Immunology, and Pathology

    DSpace software   copyright © 2002-2016   DuraSpace
    Contact Us | Send Feedback
    Registered Repository
    RE3 Certified
    HTML Sitemap  

     

    Browse

    All of Mountain ScholarCommunities & CollectionsDatesAuthorsTitlesSubjectsThis CollectionDatesAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software   copyright © 2002-2016   DuraSpace
    Contact Us | Send Feedback
    Registered Repository
    RE3 Certified
    HTML Sitemap