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    Role of innate immunity and angiogenesis in osteosarcoma growth and metastasis, The

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    http://hdl.handle.net/10217/39051
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    Abstract
    Osteosarcoma is the most common primary bone tumor in dogs and humans. Novel therapeutics are required since a number of patients will succumb to metastatic disease. Currently, it is known that a neoplastic mass contains more than transformed cells, but requires the presence of immune cells to create a supportive environment, and endothelial cells to form blood vessels to deliver oxygen and nutrients. Not only do these cells play a role in primary tumor growth, but they create an atmosphere conducive to invasion and metastasis, the primary cause of death for osteosarcoma patients. Therefore, ...
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    Author(s)
    Sottnik, Joseph L.

    Advisor(s)
    Dow, Steven W.; Thamm, Douglas

    Date Issued
    2010
    Format
    born digital; doctoral dissertations
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Graduate Degree Program in Cell & Molecular Biology

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