Studies toward the total synthesis of microsclerodermin G
We report our studies toward the synthesis of microsclerodermin G, a cyclic hexapeptide with antifungal and antitumor activity. The dehydrotryptophan amino acid was synthesized according to literature precedents. (3R)-γ-amino-β-hydroxybutyric acid (GABOB) was synthesized according to previous methodology from our research group. An aspartate-based precursor to the pyrrolidinone moiety of microsclerodermin G was prepared in four steps from known materials. 3-amino-6-methyl-12-phenyl-2,4,5-trihydroxydodeca-7,9,11-trienoic acid (AMPTD) was prepared in seven steps from known materials; the synthesis ...
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Burnett, Cameron Moeller
Williams, Robert Michael