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    Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic

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    Abstract
    Normal human epidermal keratinocytes (NHEK) were chosen as an in vitro model for mechanistic studies into how altered regulation of differentiation may play a role in the malignant transformation process in human cells. Initially, the cytotoxicity of four petroleum-derived hydrocarbons [benzo[a]pyrene (BaP), carbazole, dibenzothiophene, and isoquinoline] was investigated using the MTT assay; however, the research direction changed to focusing on examining the cellular effects, in NHEK, of BaP, the most toxic and carcinogenic polycyclic aromatic hydrocarbon among the four, and arsenic, another ...
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    Author(s)
    Perez, Damon Scott

    Advisor(s)
    Campain, Julie; Yang, Raymond Shih-hsien, 1940-

    Date Issued
    2005
    Format
    doctoral dissertations
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    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Environmental and Radiological Health Sciences

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