Purification of phenolic glycolipid from mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is a very successful human pathogen, infecting one-third of the world's population. Although originally thought to have little to no genetic variation, Mtb has been recently shown to be distinguished to clades based on geographical distribution. Further, members of specific clades (and/or subclades) have been shown to possess differences in virulence. Several clades from Asia, Africa, and India were found to express phenolic glycolipid (PGL). PGL is absent in many North American and European clades due to gene deletion. The West Beijing strains of Mtb, HN878, W4, ...
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