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    Microglial innate and adaptive immune function modulates disease pathology in and environmental pesticide model of Parkinson's disease

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    https://hdl.handle.net/10217/235733
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    Abstract
    Parkinson's Disease (PD) is the world's foremost movement disorder with pathological features including loss of dopaminergic neurons (DAn) within the substantia nigra pars compacta (SNpc), chronic activation of glial cells, and the misfolding and aggregation of a-synuclein (a-syn). Compounding evidence gathered over the past two centuries suggests environmental exposures, genetics, and aging can induce complicated cell-to-cell interactions that evoke and facilitate chronic inflammatory states; but the role that individual glial cells, in particular microglia, have in the progression of disease ...
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    Author(s)
    Rocha, Savannah M.

    Advisor(s)
    Zabel, Mark; Tjalkens, Ronald B.

    Rights Access
    Embargo Expires: 08/22/2023

    Date Issued
    2022
    Format
    born digital; doctoral dissertations
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    • 2020- CSU Theses and Dissertations
    • Theses and Dissertations - Department of Microbiology, Immunology, and Pathology

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