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    Reframing viral infections as acute metabolic disorders: dengue viruses and their dependency on host metabolic pathways

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    https://hdl.handle.net/10217/235682
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    StClair_colostate_0053A_17265.pdf (8.697Mb)
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    Abstract
    Dengue viruses (DENVs) are the etiological agent of the world's most aggressive arthropod-borne disease. At present, there are no available antivirals against DENVs. This fact underscores a dire need to examine host-virus interactions to identify and develop novel therapeutic approaches. As obligate intracellular parasites, DENVs are reliant upon and hijack several host metabolic pathways both to fulfill their replicative needs, and to evade the host immune response. We and others have previously established that infection with DENVs causes significant perturbation to host lipid metabolism, ...
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    Author(s)
    St. Clair, Laura A.

    Advisor(s)
    Perera, Rushika

    Date Issued
    2022
    Format
    born digital; doctoral dissertations
    Collections
    • 2020- CSU Theses and Dissertations
    • Theses and Dissertations - Department of Microbiology, Immunology, and Pathology

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