Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans
Altmetrics
Abstract
Alzheimer's disease is one of the most common neurodegenerative disorders and is typically characterized by the accumulation of the misfolded proteins Amyloid-Beta (Aβ1-42) and/or hyperphosphorylation of Tau (p-Tau). Despite the lack of a cure for the disease, it is well known that targeting signaling pathways involved in reactive oxygen species (ROS) or the unfolded protein response (UPR) mitigates the toxic effects of misfolded proteins, including behavioral deficits, glial inflammation, and neuronal toxicity. Laboratory animals, which have long been used to study this disease, have been ...
(For more, see "View full record.")