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    Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans

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    https://hdl.handle.net/10217/235653
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    Abstract
    Alzheimer's disease is one of the most common neurodegenerative disorders and is typically characterized by the accumulation of the misfolded proteins Amyloid-Beta (Aβ1-42) and/or hyperphosphorylation of Tau (p-Tau). Despite the lack of a cure for the disease, it is well known that targeting signaling pathways involved in reactive oxygen species (ROS) or the unfolded protein response (UPR) mitigates the toxic effects of misfolded proteins, including behavioral deficits, glial inflammation, and neuronal toxicity. Laboratory animals, which have long been used to study this disease, have been ...
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    Author(s)
    Gilberto, Vincenzo S.

    Advisor(s)
    Moreno, Julie A.

    Rights Access
    Embargo Expires: 08/22/2023

    Date Issued
    2022
    Format
    born digital; masters theses
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    • 2020- CSU Theses and Dissertations
    • Theses and Dissertations - Department of Environmental and Radiological Health Sciences

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