Noncytopathic type 2 bovine viral diarrhea virus 96B2222 induces upregulation of type-I interferon and chemokine receptor 4 expression in bovine peripheral blood mononuclear cells during in vitro infection
Altmetrics
Abstract
Bovine viral diarrhea virus (BVDV) infection leads to monetary losses in cattle operations due to morbidity and impaired growth. IT is not currently possible to identify pregnant cattle carrying fetuses persistently infected (PI) with BVDV. We previously described a type-I interferon (IFN-I) response to acute non-cytopathic (ncp) BVDV infection in PI fetuses. It was hypothesized that infection of peripheral blood mononuclear cells (PBMC) with ncp-2 96b2222 BVDV would: (1) up-regulate IFN-stimulated genes (IFN-(3, ISG 15), antiviral molecules (retinoic acid inducible gene I, RIG- 1) and chemokine ...
(For more, see "View full record.")