Vascular endothelium glycocalyx-mimetic surfaces designed for blood contacting devices
Each year millions of blood-contacting devices are used in clinical scenarios, with contact durations designed to range anywhere from hours to years. Current blood-contacting devices can perform their intended purposes well but require the assistance of systemic drugs to inhibit failure via unfavorable interactions between the material's surface and the surrounding biology. The drugs used to inhibit failure of these devices are associated with side effects that can cause increased morbidity of patients because of their systemic administration. Thus, there is a need to design materials that can ...
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