CHARACTERIZATION OF GRCC1 AND GRCC2 PRENYL DIPHOSPHATE SYNTHASES POTENTIALLY INVOLVED IN MENAQUINONE SYNTHESIS IN MYCOBACTERIUM TUBERCULOSIS, AND A HOMOLOGOUS ENZYME (MS1133) IN MYCOBACTERIUM SMEGMATIS
Characterization of GrcC1 and GrcC2 prenyl diphosphate synthases potentially involved in menaquinone synthesis in Mycobacterium tuberculosis, and a homologous enzyme (MS1133) in Mycobacterium smegmatis Biosynthesis pathways provide attractive drug targets in Mycobacterium tuberculosis. Understanding the biochemistry of the enzymes that are involved in those pathways is very important to make an achievement in this field. Menaquinones are the major lipoquinones found in M. tuberculosis and their synthesis has been suggested to be a valid drug target in this bacterium. Menaquinone is a key ...
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