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    Pharmacokinetic investigation of chloroquine analogues in cancer autophagy modulation, A

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    https://hdl.handle.net/10217/219596
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    Abstract
    Hydroxychloroquine (HCQ) is currently being investigated for safety and efficacy as an autophagy inhibitor in Phase I/II cancer clinical trials. It is the only clinically-approved autophagy inhibitor for use in cancer clinical trials in the United States. HCQ is used in combination with other chemotherapeutics to augment their efficacy and has shown moderate success in treating patients with late stage cancers. While HCQ has a good safety index and shows promise as an addition to standard of care treatment regimens, it suffers from several critical pharmacologic shortcomings which we take steps ...
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    Author(s)
    Collins, Keagan P.

    Advisor(s)
    Gustafson, Daniel

    Date Issued
    2020
    Format
    born digital; doctoral dissertations
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    • 2020- CSU Theses and Dissertations
    • Theses and Dissertations - School of Biomedical Engineering

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