In vitro and in vivo characterization of RAD51AP1 in homologous recombination DNA repair
Cancer embodies a large group of diseases that is responsible for illness and deaths in millions of people annually around the world. Many tumors arise due to accumulated, unrepaired damage and alterations to genes, from endogenous or exogenous sources of DNA damage. Among the DNA lesions associated with cancer, DNA double-strand breaks (DSBs) are considered the most dangerous and require coordinated and conserved machinery to prevent unfavorable consequences, such as apoptosis and cancer-causing mutations. One crucial DNA repair pathway for mending DSBs and maintaining genome integrity is ...
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