Targeting protein kinase C in an autoimmune diabetes mouse model
Protein kinase C, a family of intracellular signal transducing proteins, are critical for a myriad of cellular actions with implications in both diabetes and its complications. The isoform PKCθ is enriched in T lymphocytes and functions to mediate signal transduction during T cell receptor stimulation. PKCθ has been shown to play a role in T cell mediated autoimmunity, whereby its activation increases autoimmune T cell function and suppresses that of regulatory T cells. We hypothesize that specific inhibition of PKCθ in autoimmune diabetes will enhance islet tolerance, increase regulatory T cell ...
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