Reevaluating the functional role of the C₂A domain of synaptotagmin in neurotransmitter release
Efficient cell-to-cell communication is critical for nervous system function. Fast, synchronous neurotransmission underlies this communication. Following depolarization of the nerve terminal, Ca2+ enters the presynaptic cell and drives fusion of vesicles with the membrane, releasing neurotransmitter. The synaptic vesicle protein, synaptotagmin, was identified as the Ca2+ sensor for this fast, synchronous neurotransmitter release. It is hypothesized that Ca2+ binding by synaptotagmin acts as an electrostatic switch. At rest, vesicles are in a state of variable priming with repulsion between ...
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