Gene regulation by let-7 microRNAs during human and sheep placental development
Intrauterine growth restriction (IUGR) is a major cause of perinatal morbidity and mortality and affects more than 30 million infants every year across the world. Its occurrence is 5–15% of all pregnancies in the United States and 10-55% in developing countries. Most common etiology of IUGR is impaired placental development. Structural and functional abnormalities in placenta can also lead to preeclampsia (PE), still birth and spontaneous abortion. Conditions like IUGR and PE are usually not detected until later stages of gestation. Hence, there is a need to better understand the placental ...
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