Regulation of dynein activity during spindle positioning in budding yeast
Cytoplasmic dynein is a minus-end directed, microtubule motor that is highly regulated to ensure it is targeted to the correct location at a specific time for its function in cells. This is particularly important for the process of spindle positioning during mitosis. Dynein is targeted to the cell cortex and activated to pull on astral microtubules attached to spindle poles to move the spindle into position at the site of cytokinesis. The position of the spindle dictates the plane of division and influences whether a cell divides asymmetrically or symmetrically- an important distinction during ...
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