Immunogenicity against a vaccinia virus-vectored oral plague vaccine in black-footed ferrets (Mustela nigripes)
Black-footed ferrets (Mustela nigripes) are one of the most endangered mammals in North America, in part because they suffer high mortality when infected by plague, caused by the bacterium Yersinia pestis. An injectable plague vaccine is effective in black-footed ferrets but protecting wild ferrets is laborious because of the need to capture and handle these animals. In contrast, an orally delivered vaccine could be more easily distributed, as is the case with the Yersinia Pestis Vaccine that effectively protects the ferrets' main prey, prairie dogs. We evaluated in black-footed ferrets the ...
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