Evaluation of myofiber remodeling and skeletal muscle inflammaging using a novel guinea pig model, The
Approximately 40% of total body mass is accounted for by the musculoskeletal system and thus, when it becomes dysfunctional it strongly influences whole body function. Sarcopenia is one facet of musculoskeletal aging and contributes to other age-related chronic diseases. Aging is a major risk factor for osteoarthritis, which is characterized by a concomitant loss of skeletal muscle, further contributing to decreased mobility. Age-related increases in low-grade inflammation and oxidative stress, referred to as the "inflammaging" phenotype, is common to both osteoarthritis and sarcopenia. While ...
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