Sex-dependent function and regulation of the hypothalamic pituitary adrenal axis
Physiological responses to stressors are largely governed by a neuroendocrine axis, the hypothalamic pituitary adrenal (HPA) axis. Whereas HPA activation is necessary for body wide adaptation to a stressor via the production of glucocorticoids, its excessive or inappropriate activation can increase risk for a number of diseases. Importantly, many of these stress-related diseases exhibit a strong sex bias in prevalence, which may be related to sex differences in the activity of the HPA axis. Thus, the studies described in this dissertation examine sex differences in the regulation and function ...
(For more, see "View full record.")
Heck, Ashley L.