PH-dependent activity and the protonophoric mechanism of pyrazinoic acid and its structural analogues, The
Pyrazinamide is an anti tubercle drug used in the standard treatment regimen against Mycobacterium tuberculosis, the cause of tuberculosis infections. The mechanism of action of pyrazinamide requires its enzymatic conversion to pyrazinoate, but the final molecular target of pyrazinoate is controversial. Pyrazinamide also exhibits pH dependent activity in vitro, but the phenomenon was seldom explained by the mechanisms of action proposed in literature. Moreover, pyrazinamide is known to synergize with other anti mycobacterial drugs in vivo but reports of this synergistic activity in vitro are ...
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