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    Neuroinflammation and the two-hit hypothesis of Parkinson's disease

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    https://hdl.handle.net/10217/199792
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    Bantle_colostate_0053A_15764.pdf (4.707Mb)
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    Abstract
    The ever-increasing prevalence of neurodegenerative diseases, Alzheimer's Disease (AD) and Parkinson's disease (PD), impose one the most significant medical and public health threats throughout the world. Characteristic PD symptoms include loss of voluntary motor control due to α-synuclein protein-aggregation, neuroinflammatory glial activation, mitochondrial dysfunction, oxidative stress, and progressive neuronal loss. There are currently no disease-modifying therapies for the disease nor has the etiology of PD been elucidated. Epidemiologic and experimental evidence suggests that genetic ...
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    Author(s)
    Bantle, Collin M., author; Tjalkens, Ronald B., advisor; Zabel, Mark, committee member; Moreno, Julie, committee member; Kato, Takamitsu, committee member; Randall, Elissa K., committee member

    Date Issued
    2019
    Format
    born digital; doctoral dissertations
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    • 2000-2019
    • Theses and Dissertations

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