Signaling by K63-linked polyubiquitin in autophagy-related vesicular trafficking
In eukaryotic cells, endocytosis and autophagy represent fundamental pathways that contribute to cell homeostasis. Intersection of the endocytic and autophagosomal trafficking routes has been previously recognized, as both systems share specific compartments contributing to cargo degradation via the lysosome, and both use an identical subset effectors involved in vesicular trafficking and membrane fusion. By helping to target proteins to the lysosome, ubiquitin (Ub) also acts as a common factor in both pathways. The relative contributions of endocytic and autophagy pathways to degradation of ...
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