Evaluation of allogeneic bone marrow-derived mesenchymal stem cells for use in equine joints: in vitro to preclinical evaluation
Joint disease is prominent in the equine population and horses provide a highly translational model for human joint disease. Mesenchymal stem cells (MSCs) have been investigated as a treatment of musculoskeletal disease in the horse with autologous MSCs showing promise as a treatment of desmitis, tendonitis and joint disease including meniscal injury and osteoarthritis. However, the culture expansion of autologous MSCs is both labor intensive and time consuming with an average expansion time of 2-4 weeks. Allogeneic MSCs would offer multiple potential advantages over autologous MSCs use including ...
(For more, see "View full record.")