Cartilage repair using trypsin enzymatic pretreatment combined with growth-factor functionalized self-assembling peptide hydrogel
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Abstract
Treatment of cartilage defects remains challenging in the orthopedic field. Several techniques are currently available to treat cartilage defects, with subchondral bone microfracture being the most commonly used marrow stimulation technique. However, despite satisfactory results in the short-term, clinical and functional outcomes of microfracture treated patients tend to decline over time. Improving microfracture technique using tissue engineering principles may be a more attractive way to treat cartilage defects compared to other more complex and expensive alternatives. Self-assembling peptide ...
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