Cargo induced recruitment of the endocytic adaptor Sla1 and the role of Sla1-clathrin binding in endocytosis
Clathrin-mediated endocytosis is a highly dynamic process that is essential in all eukaryotes. This process is utilized for a number of functions including the uptake of extracellular nutrients, manipulation of the plasma membrane content, downregulation of cell signaling pathways, and viral entry. While differences in protein composition, sequence, and structure do exist between species for this process, many core protein functions and the mechanistic steps involved in endocytic vesicle formation and internalization are highly conserved. This has allowed findings from one species to be applicable ...
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