Modeling effects of microvilli on somatic signal propagation
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Abstract
The electrical behavior of small compartments in neurons such as dendritic spines, synaptic terminals, and microvilli has been of interest for decades. Most of these fine structures are found in the dendrite, where most excitatory inputs are received, or in the axon where the action potential is generated and propagates. However, a recent study has shown expression of sodium voltage-gated channels (VGCs) in the soma of intrinsically photosensitive retinal ganglion cells (ipRGCs). Confocal imaging locates these sodium VGCs outside the main soma membrane, which implies that the VGCs occur in ...
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