Radiofrequency heating of nanoclusters and nanoparticles for enzyme activation
Radiofrequency (RF) fields heat magnetic nanoparticles. Applications include remote drug delivery and noninvasive cancer therapy. The underlying objective is to increase temperatures precisely where desired without heating the surroundings. Before our work, the replicable limit of this precision has been in the micrometer range. To investigate the lower limit of this concept of local heat, we explored the RF remote activation of a thermophilic enzyme, thermolysin, covalently attached to gold coated iron oxide nanoparticles (6.1 nm in core diameter). Thermolysin activity was a function of applied ...
(For more, see "View full record.")