Microfluidic culture of human hepatocytes and endothelial cells with applications in drug toxicity screening
Drug-induced liver injury (DILI) continues to be a major problem for patient health and pharmaceutical expenditures, partially due to inadequacies of current model systems for predicting hepatotoxicity prior to clinical trials. In the drug development pipeline, many platforms are implemented depending on the stage of development, the number of compounds in question, and the specific hypothesis being studied. Primary human hepatocytes (PHHs) are considered the 'gold standard' for in vitro screening, as they retain a full complement of drug metabolizing enzymes and transporters. However, PHHs are ...
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