CSU Home
    • Login
    View Item 
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2000-2019 - CSU Theses and Dissertations
    • View Item
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2000-2019 - CSU Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Microfluidic culture of human hepatocytes and endothelial cells with applications in drug toxicity screening

    Thumbnail
    Citable Link(s)
    https://hdl.handle.net/10217/189305
    Download/View
    Ware_colostate_0053A_14680.pdf (10.65Mb)
    View full record
    Altmetrics
    Abstract
    Drug-induced liver injury (DILI) continues to be a major problem for patient health and pharmaceutical expenditures, partially due to inadequacies of current model systems for predicting hepatotoxicity prior to clinical trials. In the drug development pipeline, many platforms are implemented depending on the stage of development, the number of compounds in question, and the specific hypothesis being studied. Primary human hepatocytes (PHHs) are considered the 'gold standard' for in vitro screening, as they retain a full complement of drug metabolizing enzymes and transporters. However, PHHs are ...
    (For more, see "View full record.")
    Author(s)
    Ware, Brenton R.

    Advisor(s)
    Khetani, Salman R.

    Date Issued
    2018
    Format
    born digital; doctoral dissertations
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Graduate Degree Program in Bioengineering

    DSpace software   copyright © 2002-2016   DuraSpace
    Contact Us | Send Feedback
    Registered Repository
    RE3 Certified
    HTML Sitemap  

     

    Browse

    All of Mountain ScholarCommunities & CollectionsDatesAuthorsTitlesSubjectsThis CollectionDatesAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software   copyright © 2002-2016   DuraSpace
    Contact Us | Send Feedback
    Registered Repository
    RE3 Certified
    HTML Sitemap