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    Engineering complex liver models for drug screening and infectious diseases: a biomaterials and co-culture perspective

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    https://hdl.handle.net/10217/189267
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    Abstract
    In vitro liver models have many applications in disease modeling and drug screening. Micropatterned cocultures (MPCCs) of primary human hepatocytes (PHHs) and supportive stromal cells have been shown to display high hepatic functions for long-term drug and disease studies. However, MPCCs lack liver non-parenchymal cells (NPCs) and the proper microenvironmental cues that can play important roles in conditions such as drug-induced liver injury (DILI), which is the leading cause of the prelaunch attrition and post-market withdrawal of pharmaceuticals, or diseases such as viral hepatitis. Hepatitis ...
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    Author(s)
    Lin, Christine

    Advisor(s)
    Khetani, Salman R.

    Date Issued
    2018
    Format
    born digital; doctoral dissertations
    Collections
    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Graduate Degree Program in Bioengineering

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