Role of fatty acids on endoplasmic reticulum proteostasis in non-alcoholic fatty liver disease, The
Non-alcoholic fatty liver disease (NAFLD) is currently a significant health concern in both adults and children. NAFLD is a disease characterized by accumulation of fat in the liver (steatosis) in the absence of chronic alcohol consumption. In some individuals, steatosis progresses to non-alcoholic steatohepatitis (NASH), which is characterized by steatosis, inflammation, apoptosis and fibrosis, and can ultimately lead to end-stage liver disease. The underlying causes of NAFLD are unclear, although recent evidence has implicated the endoplasmic reticulum (ER) in both the development of steatosis ...
(For more, see "View full record.")