Synthetic studies of ecteinascidin 743 and fennebricin B
Ecteinascidin 743 (Et-743, trabectidin or Yondelis®) possesses an impressive antitumor activity that it was approved for treatments of several cancer types worldwide. Since this natural product only presents as a trace amount in the nature, the main supply of this drug for research and commercial use is from laboratory synthesis. Many syntheses of Et-743 have been reported including three total syntheses, two formal syntheses and two semisyntheses. The biological activities of fennebricin B were unknown due to the scarcity of this natural product. However, fennebricin B share a common pentacyclic ...
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