Subcutaneous fat: a protector from metabolic dysregulation
Lower body subcutaneous adipose tissue (LBSAT) is proposed to be a protective fat depot functioning as a “metabolic sink” for excess lipid accumulation. We have previously demonstrated that removal of this LBSAT in high fat diet (HFD) mice resulted in increased muscle triglycerides and was associated with decreased glucose tolerance. In the present study we removed varying amounts of SAT to comprehensively investigate mechanisms of the “metabolic sink” concept. Overall, accumulative fat removal worsens muscle insulin sensitivity and glucose tolerance. This decline may be related to lipid ...
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