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Subcutaneous fat: a protector from metabolic dysregulation

Date

2017

Authors

Booth, Andrea, author
Magnuson, Aaron, author
Fouts, Josephine, author
Broeckling, Corey, author
Wei, Rosie, author
Wang, Dong, author
Pagliassotti, Michael, author
Foster, Michelle, author

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Abstract

Lower body subcutaneous adipose tissue (LBSAT) is proposed to be a protective fat depot functioning as a “metabolic sink” for excess lipid accumulation. We have previously demonstrated that removal of this LBSAT in high fat diet (HFD) mice resulted in increased muscle triglycerides and was associated with decreased glucose tolerance. In the present study we removed varying amounts of SAT to comprehensively investigate mechanisms of the “metabolic sink” concept. Overall, accumulative fat removal worsens muscle insulin sensitivity and glucose tolerance. This decline may be related to lipid intermediates contained within the muscle.

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Subject

subcutaneous adipose tissue
lipectomy
glucose intolerance
muscle insulin resistance
metabolic sink
muscle lipids

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