3-chloro-p-toluidine hydrochloride metabolism and detection of exposure in birds
The avicide 3-chloro-4-methylanaline hydrochloride (chloro-p-toluidine hydrochloride, CPTH, DRC-1339) is used to control pest bird species that damage agricultural crops. While it is theorized that CPTH is a nephrotoxin, no definitive assessment of the mode of action has been performed. Additionally, the metabolic pathway of CPTH in birds has yet to be elucidated. Radioactively labeled [14C]-3-chloro-4-methylaniline hydrochloride (250 µg per bird) was delivered to 21 red-winged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and ...
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