Telomeric double strand breaks undergo resection - but not repair - in G1 human cells
Telomeres are specialized G-rich repetitive regions at the ends of eukaryotic chromosomes (TTAGGGn in mammalian cells). Telomeres function to prevent double strand break (DSB) repair activities at chromosome ends, in order to avoid fusion events which result in lethal dicentric chromosomes. Telomeric repeats make up an appreciable amount of genomic DNA (1-15kb per chromosome end). Therefore, an interesting question becomes, how is the inevitable DSB occurring within a telomere dealt with by the cell? It has been suggested that DSBs within telomeric DNA may not be repaired at all, as DSB DNA ...
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