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    Computational modeling of the pharmacokinetics and pharmacodynamics of selected xenobiotics

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    http://hdl.handle.net/10217/178903
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    Zurlinden_colostate_0053A_13947.pdf (3.159Mb)
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    Abstract
    The determination of important endpoints in toxicology and pharmacology continues to involve the acquisition of large amounts of data through resource-intensive experimental studies involving a large number of resources. Because of this, only a small fraction of chemicals in the environment and marketplace can reasonably be evaluated for safety, and many promising drug candidates must be eliminated from consideration based on inadequate evaluation. Promisingly, advances in biologically-based computational models are beginning to allow researchers to estimate these endpoints and make useful ...
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    Author(s)
    Zurlinden, Todd J.

    Advisor(s)
    Reisfeld, Brad

    Date Issued
    2016
    Format
    born digital; doctoral dissertations
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    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Chemical and Biological Engineering

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