Development of an insturmal method to evaluate insulin receptors and insulin-like growth factor-1 receptors homodimers and hybrid receptors in breast cancer
Breast cancer is a major public health problem in the United States and many other parts of the world. It is the second most common cancer and second leading cause of cancer death among women in the US. Insulin receptors (IR) and insulin-like growth factor-1 receptors (IGF1R) are found in normal mammary gland cells where they are involved in normal development and differentiation of these cells. There is substantial clinical, epidemiological, and experimental evidence indicating that these receptors are also involved in initiation and progression of neoplasia of mammary gland cells. IR and ...
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