Effects of the histone chaperone and histone modifications on nucleosome structure, The
The nucleosome, composed of 147-bp DNA and a histone octamer, is the basic unit of chromatin in eukaryotes, which is considered as a barrier for all DNA dependent processes. Understanding how nucleosome structure is regulated provides new insights into pivotal cellular processes. Histone modifications and histone chaperones have potential roles in the regulation of nucleosome structure. Here, I investigated the role of FACT in regulating nucleosome structure. FACT (FAcilitate Chromatin Transcription) is a conserved histone chaperone that is essential for gene transcription elongation. Our ...
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born digital; doctoral dissertations
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Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter Author(s):Kolean, Jennica LauraDate Issued:2010Format:masters thesesThe human genome is packaged to fit within the confines of the nucleus through the interaction with four core histone proteins, H2A, H2B, H3 and H4. These proteins organize the genetic material, however they also make it ...
Author(s):Long, Lindsey J.Date Issued:2014Format:born digital; doctoral dissertationsIn eukaryotes plasticity of chromatin architecture is paramount to allow proper regulation of processes such as transcription regulation, DNA repair, and DNA replication. Modulation of chromatin dynamics is primarily ...
Author(s):Gu, YajieDate Issued:2018Format:born digital; doctoral dissertationsThe eukaryotic genome is highly packed with histones to form chromatin. The basic building unit of chromatin is the nucleosome, which consists of a histone octamer core, wrapped by 147 base pairs of DNA. The nature of the ...