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dc.contributor.advisorDonahue, Tammy
dc.contributor.authorRemley, Katherine
dc.contributor.committeememberJames, Sue
dc.contributor.committeememberEasley, Jeremiah
dc.date.accessioned2016-08-18T23:10:16Z
dc.date.available2016-08-18T23:10:16Z
dc.date.issued2016
dc.descriptionIncludes bibliographical references.
dc.description2016 Summer.
dc.description.abstractMeniscal injuries compose 15% of all knee injuries, most often sports-related. Due to the meniscus's avascular nature, healing is difficult and injury often results in a partial meniscectomy. Research has shown meniscectomies drastically decrease contact area between the femur and tibia and increase strains experienced by the meniscus. This additional strain predisposes the knee to developing post-traumatic osteoarthritis. Poloxamer 188 (P188) is a non-ionic, amphillic surfactant that may have the ability to prevent cell death through selective insertion into the cell membrane. This in turn may prevent damaged cell signaling and reduce overall tissue degradation. While P188 has been studied and shown promise in mitigating cell death in cartilage, the effects of P188 on the meniscus are unknown. To investigate the effects of P188 on the meniscus, the goals of this project were to: 1) create a user friendly graphical user interface for a custom bioreactor capable of displacement control for precise loading of meniscal explants to physiological and supraphysiological strains; 2) determine the efficacy of P188 in mitigating meniscal tissue damage through cell viability, mechanical data and histological analysis.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifier.urihttp://hdl.handle.net/10217/176679
dc.languageEnglish
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019 - CSU Theses and Dissertations
dc.rightsCopyright of the original work is retained by the author.
dc.titleDeterming the efficacy of Poloxamer 188 (P188) in meniscal damage prevention
dc.typeText
dcterms.rights.dplaThe copyright and related rights status of this Item has not been evaluated (https://rightsstatements.org/vocab/CNE/1.0/). Please refer to the organization that has made the Item available for more information.
thesis.degree.disciplineBioengineering
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)


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