Environmental maintenance and transmission of Francisella tularensis in cottontail rabbits, prairie voles, and amoebae
Tularemia is a zoonotic disease that is endemic in much of the Northern Hemisphere, capable of causing severe disease in a wide range of hosts. This disease is caused by the gram-negative bacterium Francisella tularensis and most human cases are caused by either subsp. tularensis (type A) or holarctica (type B). Genetic clustering has led to further differentiation within type A and type B strains; type A strains are currently classified as A1a, A1b, and A2. Due to the high virulence and low infectious dose of this pathogen, naïve immune status of the public, and previous weaponization, F. ...