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    Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle

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    http://hdl.handle.net/10217/170373
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    Chaplin_colostate_0053A_13348.pdf (1.634Mb)
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    Abstract
    Resistance arteries are a major point of physiological regulation of blood flow. Increases in vessel wall stress or sympathetic activity stimulate vascular wall angiotensin signaling, resulting in smooth muscle contraction which directly increases peripheral resistance. Calcium influx through voltage-gated L-type calcium channels underlies vascular smooth muscle contraction. Roughly half of calcium influx in these cells occurs through a small number of persistently active channels, whose activity increases with membrane depolarization. The number of channels gating in this manner is increased ...
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    Author(s)
    Chaplin, Nathan L., author; Amberg, Gregory, advisor; DeLuca, Jennifer, committee member; Tamkun, Michael, committee member; Tsunoda, Susan, committee member

    Date Issued
    2015
    Format
    born digital; doctoral dissertations
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    • 2000-2019
    • Theses and Dissertations

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