Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility
Given the ongoing obesity epidemic, in which more women in the US are overweight or obese than are lean, the impact of obesity on the development of breast cancer is an important public health concern. Obese women with breast cancer generally have larger tumors and poorer prognosis than lean women with breast cancer. In an effort to deconstruct the biological mechanisms that link obesity and breast cancer, we have developed a novel rat model with high relevance to the polygenic development of obesity and breast cancer in humans. These rats have differing susceptibility to obesity when fed a diet ...
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