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    Do mesenchymal stromal cells abrogate the immune response in massive cortical allograft recipients?

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    http://hdl.handle.net/10217/167236
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    Abstract
    OBJECTIVE: To evaluate the humoral and cellular immune response against bone associated antigens when delivered in a vaccine, and to evaluate the immunomodulation on the aforementioned immune response with the addition of adipose-derived mesenchymal stromal cells (AD-MSCs). ANIMALS: 68 C57BL/6 mice PROCEDURES: Femur fragments harvested from Balb/C or C57BL/6 mice were resuspended in PBS and cationic liposomal DNA complexes (CLDC) to create an allograft or autograft vaccine, respectively. A positive control vaccine was created utilizing bovine alkaline phosphatase (ALP) resuspended in PBS and ...
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    Author(s)
    McNamara, Kaitlyn Louise

    Advisor(s)
    Ehrhart, Nicole; Dow, Steven

    Date Issued
    2015
    Format
    born digital; masters theses
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    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Clinical Sciences

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