Connecting Structural Changes to Cell Transformation Patterns in the Canine Degenerative Mitral Valve
Degenerative mitral valve disease (DMVD) is a significant problem in the canine population and also affects humans. Recent studies have provided insight into molecular and cellular mechanisms that likely contribute to disease progression. Better understanding of the cellular processes that mediate the degenerative process could lead to treatments that prevent or slow this degeneration benefiting both canine and human patients. Structural changes to degenerative valves such as nodules, leaflet thickening, increased opacity, loss of elasticity and loss of valve architecture have been well documented. ...