Manipulation and characterization of proopiomelanocortin (POMC) neurons in the hypothalamic regulation of energy balance
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It is well documented that hypothalamic proopiomelanocortin (POMC) neurons are a critical component in the maintenance of energy balance. POMC neurons release peptide transmitters that modulate pathways involved in food intake, energy expenditure, and reward pathways. POMC peptide release can result in the inhibition of food intake and increased activation of these cells is thought to precipitate the development of anorexia in the activity-based anorexia (ABA) rodent model. Currently, the physiological underpinnings that drive the development of anorexia are not fully understood, but evidence ...