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dc.contributor.advisorBell, Christopher
dc.contributor.authorBinns, Scott Edward
dc.contributor.committeememberRyan, Elizabeth
dc.contributor.committeememberHickey, Matthew
dc.date.accessioned2015-08-28T14:35:13Z
dc.date.available2016-08-14T06:30:24Z
dc.date.issued2015
dc.descriptionIncludes bibliographical references.
dc.description2015 Summer.
dc.description.abstractINTRODUCTION: Obesity is associated with increased risk of developing cardiometabolic disease characterized by decreased insulin sensitivity, positive energy balance, and cardiovascular disease. Separately, the dietary compounds curcumin (CUR) and alpha lipoic acid (ALA) increase energy expenditure and insulin sensitivity. However the efficacy of combined CUR and ALA supplementation to improve characteristics of cardiometabolic health in overweight humans has never been evaluated. METHODS: 11 overweight and sedentary adults were randomly assigned to a placebo (n=5; age: 44 ± 8 years; body mass index: 31.9 ± 2.1 kg/m²; VO₂peak: 26.8 ± 4.1 ml/kg/min; (mean ± SE)) or CUR+ALA (n=6; age: 38 ± 7 years; body mass index: 32.2 ± 1.2 kg/m²; VO₂peak: 24.9 ± 3.7 ml/kg/min) 12-week intervention. Measurements of resting metabolic rate (RMR) and thermic effect of feeding (TEF) via indirect calorimetry, and insulin sensitivity via the hyperinsulinemic euglycemic clamp technique were assessed in a pre/post treatment manner. Additionally, resting blood pressure, and body composition via dual energy x-ray absorptiometry (DEXA) were measured. RESULTS: 12-weeks of CUR+ALA supplementation did not change RMR (1467 ± 89.9 to 1539 ± 94.4 kcal/day; P=0.239) or TEF AUC (P=0.51). Additionally, no change in glucose infusion rate occurred as a result of supplementation (12.8 ± 2.1 to 12.4 ± 1.2 mg/FFM kg/min; P=0.690). Resting systolic blood pressure was unaffected in the CUR+ALA group (116 ± 3.2 to 123.8 ± 25.4 mmHg; P=0.31). Body fat percentage did not change with CUR+ALA supplementation (43.8 ± 2.2 to 41.6 ± 1.9 body fat percent; P=0.162), however, body fat percentage decreased in all subjects regardless of treatment (P=0.002). DISCUSSION: These preliminary data do not support the use of CUR+ALA to improve metabolic and cardiovascular health in overweight adults.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifier.urihttp://hdl.handle.net/10217/167123
dc.languageEnglish
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019 - CSU Theses and Dissertations
dc.rightsCopyright of the original work is retained by the author.
dc.subjecthypertension
dc.subjectsupplements
dc.subjectobesity
dc.subjectdiabetes
dc.titleCombining curcumin and alpha-lipoic acid to treat cardiometabolic syndrome
dc.typeText
dcterms.embargo.expires2016-08-14
dcterms.rights.dplaThe copyright and related rights status of this Item has not been evaluated (https://rightsstatements.org/vocab/CNE/1.0/). Please refer to the organization that has made the Item available for more information.
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)


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